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FRUCTOSE INDUCED HYPERURICEMIA PDF

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans. Virgile Lecoultre, PHD1,; Léonie Egli, MSC1,; Fanny. Fructose-induced hyperuricemia and hyperuricaciduria is associated with a striking increase in the blood lactate concentration, a decrease in erythrocyte. As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and.

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Blood glucose, lactic acid, and fructose levels were significantly increased after fructose, but serum magnesium levels did not change.

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

These samples were collected while subjects were participating in two clinical trials clinical trial reg. Fructose-induced hyperuricemia results in endothelial dysfunction hyoeruricemia insulin resistance, and might be a novel causal mechanism of the metabolic syndrome. Consistent with this hypothesis is the observation that changes in mean uric acid levels correlate with the increasing prevalence of metabolic syndrome in the US and developing countries.

fructosr In addition, we observed that a serum uric acid level above 5. It has not been assessed, however, whether UA also increases when fructose is administered as several small drinks instead of one single large load or whether a high-fructose diet HFrD impairs renal UA clearance UAC or fractional excretion UAFE as observed in rats 3.

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Fductose serum Pi level decreased 2. Animals deficient in endothelial NO develop insulin resistance and other features of the metabolic syndrome.

Open in a separate window. We recently reported that uric acid reduces levels of endothelial nitric oxide NOa key mediator of insulin action.

Furthermore, high-fructose intake over several days is associated with increased fasting UA concentration 1.

Published online Aug The serum Pi fructoss decreased less in galactosemic patients after galactose administration than in patients with HFI after fructose infusion. National Center for Biotechnology InformationU.

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

Support Center Support Center. The mean blood inorganic phosphate Pi levels were significantly less than the mean fasting value after fructose. The increasing incidence of obesity and the metabolic syndrome over the past two decades has coincided with a marked increase in total fructose intake. Allopurinol, rutin, hyperkricemia quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: This article has been cited by other articles in PMC.

Am J Clin Nutr ; Journal List Diabetes Care v. The lack of hyperruricemia in galactosemia patients after galactose ingestion may be explained by the observation that galactose is phosphorylated more slowly than fructose. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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This effect appears to be specific for fructose. Acknowledgments This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co.

In two patients with HFI the uric acid excretion increased four- to fivefold after fructose administration; the increased uric acid excretion in HFI exceeded that of normal children.

NO increases blood flow to ibduced muscle and enhances glucose uptake. Although the cumulative fructose load was large 1. Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. Closed symbols represent data collected after 4—6 days of HFrD.

Because the metabolic effects of fructose show significant sex differences, it remains to frucctose assessed whether the same effects are observed in female subjects.

These observations suggest that a decreased urinary UA excretion may contribute to fructose-induced hyperuricemia. The mean uric acid excretion, expressed as milligrams per incuced urinary creatinine, was 0.

Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition. This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co.